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3-Farnesyl-2-hydroxybenzoic acid is a new anti-Helicobacter pylori compound from Piper multiplinervium

Ruegg, T.
Calderon, A.I.
Queiroz, E.
Solis, P.N.
Marston, Andrew
Rivas, F.
Ortega-Barria, E.
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Published in Journal of Ethnopharmacology. 2006, vol. 103, no. 3, p. 461 - 467
Abstract A new prenylated salicylic acid derivative, 3-farnesyl-2-hydroxy benzoic acid (1), was isolated from the leaves of Piper multiplinervium C. DC. (Piperaceae). It showed anti-Helicobacter pylori activity (MIC 37.5 mu g/ml) and antimicrobial activity at MICs between 2.5 and 5 mu g/ml against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Mycobacterium smegmatis, Pseudonionas aeruginosa and Candida albicans. Its structure was elucidated by means of MS, H-1 and C-13 NMR. The ethnomedical claim of Piper multiplinervium to treat stomach aches by the Kuna Indians of Panama may be justified by anti-Helicobacter pylori activity of its MeOH extract. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Keywords Piper multiplinerviumAntimicrobialHelicobacter pyloriPrenylated 2-hydroxybenzoic acidKuna Indians
Stable URL http://archive-ouverte.unige.ch/unige:11030
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