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New and Bioactive Aromatic Compounds from Zanthoxylum zanthoxyloides

Queiroz, Emerson F.
Hay, Anne-Emmanuelle
Chaaib, Fatima
van Diemen, Daphné
Diallo, Drissa
Published in Planta Medica. 2006, vol. 72, no. 8, p. 746 - 750
Abstract In the course of a study of medicinal plants from Mali, the root bark of Zanthoxylum zanthoxyloides Lam. (Rutaceae) was investigated. The root bark of this plant is used as a toothbrush by West African people. Phytochemical investigation of the MeOH extract of Zanthoxylum zanthoxyloides Lam. (Rutaceae) led to the isolation of different biologically active compounds. The separation of acetylcholinesterase inhibitors was performed by centrifugal partition chromatography (CPC). The fractions were monitored by direct TLC bioautographic assays. The bio-guided isolation led to the isolation of a new peroxide derivative. In addition, LC/UV/MS analysis performed on the crude MeOH extract allowed on-line identification of some known compounds. The structures of the isolated compounds were elucidated by classical spectroscopic methods including UV, NMR, MS and HR-MS.
Keywords Zanthoxylum zanthoxyloidesRutaceaeAcetylcholinesterase inhibitorsCladosporium cucumerinumCandida albicansBacillus subtilisFree radical scavengers
Stable URL http://archive-ouverte.unige.ch/unige:11029
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