UNIGE document Scientific Article
previous document  unige:11023  next document
add to browser collection

Bioactive Diterpenes from the Fruits of Detarium microcarpum

Hay, Anne-Emmanuelle
Marston, Andrew
Stoeckli-Evans, Helen
Scopelliti, Rosario
Diallo, Drissa
Published in Journal of Natural Products. 2006, vol. 69, no. 5, p. 768 - 773
Abstract A fruit pulp extract of Detarium microcarpum showed inhibition of the growth of the plant pathogenic fungus Cladosporium cucumerinum and of the enzyme acetylcholinesterase, implicated in Alzheimer's disease. Fractionation of this extract led to the isolation of four new clerodane diterpenes, 3,4-epoxyclerodan-13E-en-15-oic acid ( 1), 5 alpha, 8 alpha-(2-oxokolavenic acid) ( 2), 3,4-dihydroxyclerodan-13E-en-15-oic acid ( 4), and 3,4- dihydroxyclerodan-13Z-en-15-oic acid ( 5). Also isolated were 2-oxokolavenic acid ( 3) and copalic acid ( 6). Structure elucidation of the compounds was carried out by spectroscopic data interpretation and by the X-ray crystallography of 2 and 4. Three of the new clerodane diterpenes ( 1, 2, and 5) showed both antifungal activity and inhibition of acetylcholinesterase, and 3 showed a slight inhibition of this enzyme.
Keywords PlantsDetarium microcarpumX-ray crystallographyAntifungal activityAcetylcholinesterase
Stable URL http://archive-ouverte.unige.ch/unige:11023
Full text
Article (Published version) (280 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://pubs.acs.org/doi/abs/10.1021/np058123q
122 hits and 0 download since 2010-08-27
Export document
Format :
Citation style :