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Saponins from fresh fruits of Randia siamensis (Lour) Roem. & Schult. (Rubiaceae)

Khwanchuea, R.
Queiroz, E.F.
Marston, Andrew
Jansakul, K.
Published in Natural Product Communications. 2008, vol. 3, p. 163-170
Abstract Bioactivity-directed fractionation of the n-butanol extract of fresh fruits of Randia siamensis led to the isolation of 4 new ginsenosides: pseudoginsenosides-RT2, -RT3, -RT4 and -RT5, together with 7 known compounds. Tyramine was found to be responsible for the hypertensive activity, whereas pseudoginsenosides-RT1 and -RP1 were responsible for the hypotensive activity. The structures were determined by spectroscopic and chemical methods.
Keywords Randia siamensisRubiaceaeTriterpene saponinsGinsenosidesHypertensive activityHypotension
Stable URL http://archive-ouverte.unige.ch/unige:11008
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