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Spontaneous production of anti-mouse red blood cell autoantibodies is independent of the polyclonal activation in NZB mice

Reininger, Luc
Shibata, T.
Schurmans, Stephane
Merino, Ramon
Fossati-Jimack, Liliane
Lacour, M.
Published in European Journal of Immunology. 1990, vol. 20, no. 11, p. 2405-2410
Abstract New Zealand Black (NZB) mice spontaneously develop an autoimmune hemolytic anemia together with a markedly increased production of polyclonal antibodies. The spontaneous generation of anti-mouse red blood cells (MRBC), anti-bromelain-treated MRBC (BrMRBC) and anti-DNA autoantibodies was compared to the polyclonal antibody formation in irradiated (800 rad) 2-month-old NZB mice reconstituted with bone marrow cells (BMC) from 2- or 10-month-old NZB mice. The injection of 10-month-old NZB BMC markedly accelerated the mortality rate in parallel with the progressive increase of anti-MRBC and anti-BrMRBC autoantibody production, but the spontaneous production of polyclonal IgM antibodies and anti-DNA autoantibodies was completely abolished down to the levels of non-autoimmune mice. In contrast, mice reconstituted with 2-month-old NZB BMC exhibited neither the acceleration of anemia nor the lack of polyclonal antibody production. These results strongly suggest that the spontaneous production of anti-MRBC autoantibodies, including anti-BrMRBC autoantibodies, in the NZB mouse occurs independently of the polyclonal B cell activation, and that they result from a specific immune stimulation, while the anti-DNA autoantibody production is a consequence of polyclonal antibody formation.
Keywords Anemia, Hemolytic, Autoimmune/etiologyAnimalsAntibodies, Antinuclear/biosynthesisAutoantibodies/ biosynthesisB-Lymphocytes/ immunologyBone Marrow TransplantationDNA/immunologyErythrocytes/ immunologyFemaleImmunoglobulin M/biosynthesisLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred NZB
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PMID: 2253680
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