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Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse

Rajput, B.
Marshall, A.
Killary, A. M.
Lalley, P. A.
Naylor, S. L.
Rickles, R. J.
Strickland, S.
Published in Somatic Cell and Molecular Genetics. 1987, vol. 13, no. 5, p. 581-586
Abstract The genes encoding the two plasminogen activators, tissue plasminogen activator and urokinase, were mapped to mouse chromosomes using probes derived from the respective mouse cDNAs. DNA from mouse-Chinese hamster and mouse-rat somatic cell hybrids was digested with BamHI and EcoRI, respectively, and analyzed by Southern blot hybridization for the segregation of the two genes. Tissue plasminogen activator and urokinase cosegregated with mouse chromosomes 8 and 14, respectively. The plasminogen activator genes thus fall into two syntenic groups that are conserved in human and mouse.
Keywords AnimalsChromosome MappingDNA/geneticsDNA Restriction EnzymesHumansHybrid CellsLinkage (Genetics)MiceNucleic Acid HybridizationRatsTissue Plasminogen Activator/ geneticsUrokinase-Type Plasminogen Activator/ genetics
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PMID: 2821634
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