The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19
|Published in||Genomics. 1992, vol. 13, no. 4, p. 1307-1310|
|Abstract||RFX1 is a transacting DNA-binding regulatory factor involved in the control of MHC class II gene expression. RFX2 is a structurally very similar protein with identical DNA binding features. A member of the family of RFX factors is affected in an autosomal recessive disease, MHC class II deficient combined immunodeficiency (CID), caused by a defect in a trans-acting regulatory factor controlling MHC class II gene expression. In situ hybridization with 3H-labeled RFX1 cDNA has allowed us to identify two distinct targets on the short arm of chromosome 19 (19p13.1 and 19p13.2-p13.3). With the use of biotinylated genomic cosmid clones specific for RFX1 and RFX2, respectively, it was then possible to localize RFX1 at 19p13.1 and RFX2 at 19p13.2-p13.3. These two regulatory genes are thus assigned to a region of high gene density and RFX1 is close to another DNA-binding factor, LYL1.|
|Keywords||Chromosome Mapping — Chromosomes, Human, Pair 19 — Dna — DNA-Binding Proteins/ genetics — Gene Expression Regulation — Genes, MHC Class II — Humans — Karyotyping — Metaphase — Nucleic Acid Hybridization — Transcription Factors/ genetics/metabolism|
This document has no fulltext available yet, but you can contact its author by using the form below.