UNIGE document Scientific Article
previous document  unige:10957  next document
add to browser collection

Myofibroblastes et membranes fibrovasculaires rétiniennes

Pournaras, C. J.
Kapetanios, A. D.
Redard, M.
Published in Klinische Monatsblätter für Augenheilkunde. 1998, vol. 212, no. 5, p. 356-358
Abstract INTRODUCTION: Epiretinal tissue proliferations occurring during the evolution of ischemic microangiopathies or preretinal diseases are tough to cause retinal detachment by traction mechanisms. Cellular migration/proliferations and finally contraction are tough to be the pathogenic element. Myofibroblasts are contractile cells having features intermediate between those of the fibroblasts and smooth muscle. We conducted a study to explore whether such cells are present in preretinal membranes. MATERIALS AND METHODS: 8 membranes, preelevated during vitrectomy for proliferative vitreoretinopathy or diabetic proliferative vitreoretinopathy, were analysed with immunostaining technique searching for alpha-actine smooth muscle, desmine, which are specific markers for myofibroblasts and TGF-beta1, that is considered as the mean factor promoting the transformation of fibroblasts into myofibroblasts. RESULTS: All the histological preparation showed abundant staining with antibody against alpha-actine smooth muscle, desmine and TGF-beta1. CONCLUSIONS: Myofibroblasts are one of the major cellular element of preretinal membranes. They are scattered throughout the membrane and seem to account for their contractile properties.
Keywords Actins/metabolismCell Division/ physiologyCell Movement/physiologyDesmin/metabolismDiabetic Retinopathy/ pathologyEpiretinal Membrane/ pathologyFibroblasts/pathologyHumansMyosins/metabolismRetinal Detachment/pathologyTransforming Growth Factor beta/metabolismVitreoretinopathy, Proliferative/ pathology
Stable URL http://archive-ouverte.unige.ch/unige:10957
Full text
PMID: 9677578
150 hits and 0 download since 2010-08-26
Export document
Format :
Citation style :