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Hyperprolactinemia in male NZB/NZW (B/W) F1 mice: accelerated autoimmune disease with normal circulating testosterone

McMurray, R.
Keisler, D.
Walker, S. E.
Published in Clinical Immunology and Immunopathology. 1994, vol. 71, no. 3, p. 338-343
Abstract It has been proposed that the immunostimulatory hormone, prolactin, is associated with flares of systemic lupus erythematosus (SLE). In autoimmune female NZB/NZW F1 (B/W) mice with accelerated lupus-like disease, hyperprolactinemia accelerated autoimmunity. The current study explored effects of moderate and severe hyperprolactinemia in male B/W mice, which have late-onset SLE. Autoimmune disease in B/W males was assessed by measurement of anti-DNA antibodies (anti-DNA), gp70-anti-gp70 immune complexes (gp70IC), IgM, IgG, and renal function. Serum testosterone concentrations were assayed serially. All mice were necropsied when moribund. Hyperprolactinemic B/W males were characterized by premature appearance of anti-DNA and gp70IC and elevation of IgM and IgG. Hyperprolactinemia accelerated mortality with vasculitis and renal disease compared to control mice. Serum testosterone concentrations were not suppressed. In male B/W mice, chronic hyperprolactinemia stimulated autoimmune disease activity; the deleterious effects of prolactin were not mediated through suppression of the immunoprotective hormone, testosterone. This observation supports the proposed association between elevated prolactin levels and exacerbations of SLE.
Keywords AnimalsAntibodies, Antinuclear/analysisAutoimmune Diseases/etiologyBlood Urea NitrogenBody WeightDisease Models, AnimalFemaleGlycoproteins/bloodHematocritHyperprolactinemia/ metabolismImmunoglobulins/bloodLeukocyte CountLupus Erythematosus, Systemic/metabolismMaleMiceProlactin/bloodTestosterone/blood
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PMID: 8200135
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