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Relevance of polyclonal antibody formation to the development of autoimmunity : the model of African trypanosomiasis

Louis, J. A.
Kobayakawa, T.
Published in Advances in Experimental Medicine and Biology. 1979, vol. 114, p. 667-671
Abstract There is an induction of anti-DNA antibodies in mice following the administration of bacterial lipopolysaccharides, Dextran sulfate and PPD, which is closely associated with the property of these substances to trigger a polyclonal B cell activation. In the experiments model of African trypanosomiasis there is also an intense polyclonal antibody synthesis paralleled by the formation of several autoantibodies: anti-DNA, anti-bromelain treated mouse red blood cells and antithymocyte antibodies.
Keywords AnimalsAutoantibodies/ biosynthesisB-Lymphocytes/immunologyClone Cells/immunologyDNA/biosynthesisDextrans/pharmacologyDisease Models, AnimalHemolytic Plaque TechniqueLipopolysaccharides/pharmacologyMiceMice, Inbred C3HMice, NudePoly I-C/pharmacologyT-Lymphocytes/immunologyTrypanosomiasis, African/ immunologyTuberculin/immunology
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