Relevance of polyclonal antibody formation to the development of autoimmunity : the model of African trypanosomiasis
|Published in||Advances in Experimental Medicine and Biology. 1979, vol. 114, p. 667-671|
|Abstract||There is an induction of anti-DNA antibodies in mice following the administration of bacterial lipopolysaccharides, Dextran sulfate and PPD, which is closely associated with the property of these substances to trigger a polyclonal B cell activation. In the experiments model of African trypanosomiasis there is also an intense polyclonal antibody synthesis paralleled by the formation of several autoantibodies: anti-DNA, anti-bromelain treated mouse red blood cells and antithymocyte antibodies.|
|Keywords||Animals — Autoantibodies/ biosynthesis — B-Lymphocytes/immunology — Clone Cells/immunology — DNA/biosynthesis — Dextrans/pharmacology — Disease Models, Animal — Hemolytic Plaque Technique — Lipopolysaccharides/pharmacology — Mice — Mice, Inbred C3H — Mice, Nude — Poly I-C/pharmacology — T-Lymphocytes/immunology — Trypanosomiasis, African/ immunology — Tuberculin/immunology|
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