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The spontaneous development of thymocytotoxic antibodies in athymic nude mice and its suppression after transfer of syngeneic thymocytes

Louis, Jacques
Published in European Journal of Immunology. 1978, vol. 8, no. 3, p. 221-223
Abstract Athymic nude mice early in life spontaneously develop a high level of thymocytotoxic antibodies which have characteristics similar to the thymocytotoxic autoantibodies occurring in young NZB mice. Thymocytotoxic activity was no longer detectable in the serum of nude mice two weeks after the intravenous injection of syngeneic thymocytes, although the levels of spontaneously occurring anti-DNA and anti-hapten antibodies were not affected by the cell transfer.
Keywords AnimalsAntibodiesAntilymphocyte SerumCytotoxicity Tests, ImmunologicDNA/immunologyDinitrobenzenes/immunologyImmunosuppressionMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLMice, Nude/ immunologyT-Lymphocytes/ immunology/transplantation
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PMID: 306927
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