Autoimmune hemolytic anemia
|Published in||Current Opinion in Immunology. 1994, vol. 6, no. 6, p. 926-930|
|Abstract||Autoimmune hemolytic anemia (AHA) is characterized by the production of Coombs' antibodies, which are responsible for the destruction of red blood cells (RBCs). Analysis of both monoclonal anti-RBC autoantibodies derived from autoimmune New Zealand black mice and transgenic mice expressing a pathogenic IgM anti-RBC autoantibody has considerably improved our understanding of the B-cell responses involved in AHA, although our knowledge of T-cell immunity in AHA is still limited. The identification of the major T-cell epitope in the context of MHC class II molecules would be of paramount importance in helping to elucidate the cellular and molecular basis central to the development of AHA.|
|Keywords||Anemia, Hemolytic, Autoimmune/genetics/ immunology — Animals — Autoantibodies/genetics/immunology — Autoantigens/immunology — Erythrocytes/immunology — Humans — Immunoglobulin M/immunology — Mice — Mice, Inbred NZB — Mice, Transgenic — T-Lymphocytes/immunology|
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