Surface proteins of radiation-induced and radiation leukemia virus-induced thymic lymphosarcomas in mice
|Published in||Leukemia Research. 1983, vol. 7, no. 2, p. 205-219|
|Abstract||Thymic lymphosarcomas (TLS) were induced in C57BL mice by X-rays or by Radiation Leukemia Virus (RadLV) and their surface glycoproteins (gps) compared after cell-surface radioiodination and polyacrylamide gel electrophoresis (SDS-PAGE). All lymphocytic antigens tested (T200, 170/100, Thy-1) and proteins with apparent molecular weight (Mr) around 120,000 and 100,000 were present on all tumours, as well as retrovirus--encoded proteins but considerable variation in the Mr of several serologically-related proteins was observed. Therefore, the TLS in C57BL mice form a heterogeneous group, suggesting that T cells can be transformed at different stages of maturation. The possibility that transformation allows or even triggers differentiation is also entertained.|
|Keywords||Animals — Antigens, Surface/analysis — Antigens, Thy-1 — Autoradiography — Electrophoresis, Polyacrylamide Gel — Female — Glycoproteins/analysis — Lymphoma, Non-Hodgkin/etiology/ metabolism — Mice — Mice, Inbred C57BL — Neoplasm Proteins/ analysis — Neoplasms, Experimental/etiology/metabolism — Neoplasms, Radiation-Induced/ metabolism — T-Lymphocytes — Tumor Virus Infections/ metabolism — Viral Proteins/analysis|
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