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Surface proteins of radiation-induced and radiation leukemia virus-induced thymic lymphosarcomas in mice

Hooghe, R.
Janowski, M.
Published in Leukemia Research. 1983, vol. 7, no. 2, p. 205-219
Abstract Thymic lymphosarcomas (TLS) were induced in C57BL mice by X-rays or by Radiation Leukemia Virus (RadLV) and their surface glycoproteins (gps) compared after cell-surface radioiodination and polyacrylamide gel electrophoresis (SDS-PAGE). All lymphocytic antigens tested (T200, 170/100, Thy-1) and proteins with apparent molecular weight (Mr) around 120,000 and 100,000 were present on all tumours, as well as retrovirus--encoded proteins but considerable variation in the Mr of several serologically-related proteins was observed. Therefore, the TLS in C57BL mice form a heterogeneous group, suggesting that T cells can be transformed at different stages of maturation. The possibility that transformation allows or even triggers differentiation is also entertained.
Keywords AnimalsAntigens, Surface/analysisAntigens, Thy-1AutoradiographyElectrophoresis, Polyacrylamide GelFemaleGlycoproteins/analysisLymphoma, Non-Hodgkin/etiology/ metabolismMiceMice, Inbred C57BLNeoplasm Proteins/ analysisNeoplasms, Experimental/etiology/metabolismNeoplasms, Radiation-Induced/ metabolismT-LymphocytesTumor Virus Infections/ metabolismViral Proteins/analysis
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PMID: 6133984
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