Detection of polymorphisms in the human urokinase-type plasminogen activator gene
|Published in||Thrombosis and Haemostasis. 1997, vol. 77, no. 3, p. 434-435|
|Abstract||Expressed polymorphisms in the genes encoding components of the fibrinolytic cascade could have implications for the predisposition to thrombolytic disorders and/or for tumor metastasis. The occurrence of published two amino acid sequences at position 194 of the human urokinase-type plasminogen activator prompted us to search by SSCP for frequent polymorphisms in several exons of the gene. Surprisingly, only one sequence was detected in codon 194 (> 200 alleles). Two polymorphisms were observed in this study: the most frequent one, a C to T change near the beginning of exon 8, is probably silent; a less frequent polymorphism results in the replacement of a Leu residue by a Pro, in the kringle domain.|
|Keywords||Alleles — Humans — Molecular Sequence Data — Polymerase Chain Reaction — Polymorphism, Genetic — Polymorphism, Single-Stranded Conformational — Sequence Analysis, DNA — Urokinase-Type Plasminogen Activator/ genetics|
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