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Detection of polymorphisms in the human urokinase-type plasminogen activator gene

Berczy, M.
Published in Thrombosis and Haemostasis. 1997, vol. 77, no. 3, p. 434-435
Abstract Expressed polymorphisms in the genes encoding components of the fibrinolytic cascade could have implications for the predisposition to thrombolytic disorders and/or for tumor metastasis. The occurrence of published two amino acid sequences at position 194 of the human urokinase-type plasminogen activator prompted us to search by SSCP for frequent polymorphisms in several exons of the gene. Surprisingly, only one sequence was detected in codon 194 (> 200 alleles). Two polymorphisms were observed in this study: the most frequent one, a C to T change near the beginning of exon 8, is probably silent; a less frequent polymorphism results in the replacement of a Leu residue by a Pro, in the kringle domain.
Keywords AllelesHumansMolecular Sequence DataPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Single-Stranded ConformationalSequence Analysis, DNAUrokinase-Type Plasminogen Activator/ genetics
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PMID: 9065988
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