UNIGE document Scientific Article
previous document  unige:10644  next document
add to browser collection
Title

Physicochemical profile and in vitro permeation behavior of a new class of non-steroidal anti-inflammatory drug candidates

Authors
Rolando, B.
Lazzarato, L.
Di Stilo, A.
Fruttero, Roberta
Gasco, Alberto
Published in European Journal of Pharmaceutical Sciences. 2010, vol. 40, p. 217-221
Abstract Recently a new series of nitrooxy-acyl derivatives of salicylic acid (SA) was described presenting similar anti-inflammatory activities but reduced or no gastrotoxicity compared to aspirin. In this work, lipophilicity and permeability profiles of SA derivatives were performed to evaluate their ADME properties related to oral or transdermic delivery. All tested compounds showed potential good passive permeation through gastrointestinal track and also through percutaneous barrier which could be a way to avoid the first hepatic pass.
Stable URL http://archive-ouverte.unige.ch/unige:10644
Full text
Identifiers
PMID: 20347036
Structures
127 hits and 1 download since 2010-08-06
Update
Export document
Format :
Citation style :