Very slow chiral inversion of clopidogrel in rats: a pharmacokinetic and mechanistic investigation
Contributeurs/tricesReist, Marianne; Roy-de Vos, M.; Montseny, J. P.; Mayer, J. M.; Carrupt, Pierre-Alain; Berger, Y.; Testa, Bernard
Publié dansDrug metabolism and disposition, vol. 28, no. 12, p. 1405-1410
Date de publication2000
Résumé
Mots-clés
- Algorithms
- Animals
- Chromatography, High Pressure Liquid
- Half-Life
- Hepatocytes/metabolism
- Hydrolysis
- Platelet Aggregation Inhibitors/metabolism/*pharmacokinetics
- Rats
- Rats, Sprague-Dawley
- Spectrophotometry, Ultraviolet
- Stereoisomerism
- Ticlopidine/*analogs & derivatives/metabolism/pharmacokinetics
Structure d'affiliation Pas une publication de l'UNIGE
Citation (format ISO)
REIST, Marianne et al. Very slow chiral inversion of clopidogrel in rats: a pharmacokinetic and mechanistic investigation. In: Drug metabolism and disposition, 2000, vol. 28, n° 12, p. 1405–1410.
Fichiers principaux (1)
Article
Identifiants
- PID : unige:10633
- PMID : 11095576
URL commercialhttp://dmd.aspetjournals.org/content/28/12/1405.full.pdf
ISSN du journal0090-9556