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Title

Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability

Authors
Ottaviani, G.
Published in Journal of Medicinal Chemistry. 2006, vol. 49, no. 13, p. 3948-3954
Abstract This work was devoted to the search for new artificial membranes allowing a rapid evaluation of passive human skin permeation of compounds with a parallel artificial membrane permeability assay (PAMPA). Effective permeability coefficients (Pe) determined for a set of compounds using the PAMPA technique with isopropyl myristate (IPM) and silicone oil, alone or in mixture, were compared to the corresponding human skin permeability coefficient values (Kp). A good correlation between Pe and Kp was found for compounds tested through a membrane consisting of 70% silicone and 30% IPM. Moreover, positive correlation between the membrane retention of compounds and stratum corneum/water partition coefficients (PSC) was established. These results showed that this new artificial membrane, defined as PAMPA-skin, is able to mimic the main barrier properties of human stratum corneum and can be used for the fast prediction of passive human skin permeability coefficients.
Keywords DiffusionDimethylpolysiloxanes/*chemistryHumansMembranes, ArtificialMyristates/*chemistryPermeabilitySkin/*metabolismSkin AbsorptionWater/chemistry
Stable URL http://archive-ouverte.unige.ch/unige:10622
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Other version: http://pubs.acs.org/doi/pdfplus/10.1021/jm060230%2B
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PMID: 16789751
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