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Title

Novel basic isoflavones as inhibitors of bone resorption

Authors
Delcanale, M.
Amari, G.
Armani, E.
Lipreri, M.
Civelli, M.
Galbiati, E.
Giossi, M.
Caruso, P. L.
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Published in Helvetica Chimica Acta. 2001, vol. 84, no. 8, p. 2417-2429
Abstract A number of aminoalkoxy analogues of ipriflavone (=7-(1-methylethoxy)isoflavone) were prepared and examined for their capacity to inhibit bone resorption induced by bovine parathyroid hormone fragment 1 - 34. Good-to-high activities were found for 7-(aminoalkoxy)isoflavone. analogues. Their activity was influenced by a number of structural features, among which the length of the basic side chain, the basicity of the amino group, and the nature and position of substituents on the 3-phenyl ring. 4'-(Aminoalkoxy)ipriflavone derivatives were less active
Stable URL http://archive-ouverte.unige.ch/unige:10566
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