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Title

VEGF is a chemoattractant for FGF-2-stimulated neural progenitors

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Published in The Journal of Cell Biology. 2003, vol. 163, no. 6, p. 1375-1384
Abstract Migration of undifferentiated neural progenitors is critical for the development and repair of the nervous system. However, the mechanisms and factors that regulate migration are not well understood. Here, we show that vascular endothelial growth factor (VEGF)-A, a major angiogenic factor, guides the directed migration of neural progenitors that do not display antigenic markers for neuron- or glia-restricted precursor cells. We demonstrate that progenitor cells express both VEGF receptor (VEGFR) 1 and VEGFR2, but signaling through VEGFR2 specifically mediates the chemotactic effect of VEGF. The expression of VEGFRs and the chemotaxis of progenitors in response to VEGF require the presence of fibroblast growth factor 2. These results demonstrate that VEGF is an attractive guidance cue for the migration of undifferentiated neural progenitors and offer a mechanistic link between neurogenesis and angiogenesis in the nervous system.
Keywords AnimalsAnimals, NewbornAntigens, Surface/metabolismBiological MarkersCell Differentiation/drug effects/physiologyCells, CulturedChemotaxis/drug effects/ physiologyCuesFibroblast Growth Factor 2/metabolism/pharmacologyNeurons/cytology/drug effects/ metabolismRatsRats, Sprague-DawleyStem Cells/cytology/drug effects/ metabolismVascular Endothelial Growth Factor A/ metabolism/pharmacologyVascular Endothelial Growth Factor Receptor-1/drug effects/metabolismVascular Endothelial Growth Factor Receptor-2/drug effects/metabolism
Stable URL http://archive-ouverte.unige.ch/unige:10528
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PMID: 14691144
Structures
Research group Progéniteurs neuronaux
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