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Title

Structural plasticity underlies experience-dependent functional plasticity of cortical circuits

Authors
Wilbrecht, Linda
Wright, Nick
Fox, Kevin
Svoboda, Karel
Published in Journal of Neuroscience. 2010, vol. 30, no. 14, p. 4927-4932
Abstract The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote alphaCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization at the border between barrel columns after whisker trimming. Our data provide a causal link between new spine synapses and plasticity of adult cortical circuits and suggest that alphaCaMKII autophosphorylation plays a role in the stabilization but not formation of new spines.
Keywords AnimalsCerebral Cortex/ physiology/ultrastructureDendritic Spines/physiology/ultrastructureLearning/ physiologyMaleMiceMice, Inbred C57BLMice, TransgenicNerve Net/ physiology/ultrastructureNeuronal Plasticity/ physiologySynapses/physiology/ultrastructureVibrissae/ physiology
Stable URL http://archive-ouverte.unige.ch/unige:10515
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Other version: http://www.jneurosci.org/cgi/content/abstract/30/14/4927
Identifiers
PMID: 20371813
Structures
Research group Les circuits neuronaux dans le néocortex des mammifères (855)
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