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Title

PSA-NCAM modulates BDNF-dependent survival and differentiation of cortical neurons

Authors
Djebbara-Hannas, Z.
Durbec, Pascale
Rougon, G.
Published in European Journal of Neuroscience. 2001, vol. 13, no. 7, p. 1391-1402
Abstract We show that the loss or inactivation of the polysialic acid (PSA) tail of neural cell adhesion molecule (NCAM) on rat cortical neurons in culture leads to reduced differentiation and survival. The mechanism by which this negative effect is mediated appears to involve the neuronal response to brain-derived neurotrophic factor (BDNF): (i) in the absence of PSA or in the presence of excess free PSA added to the culture medium, BDNF-induced cell signalling is reduced; (ii) the addition of exogenous BDNF to the medium reverses the effect of PSA loss or inactivation. These data suggest that PSA-NCAM, previously shown to modulate cell migration and plasticity, is needed for an adequate sensitivity of neurons to BDNF.
Keywords AnimalsAnimals, NewbornBrain-Derived Neurotrophic Factor/ pharmacologyCell Death/drug effects/physiologyCell Differentiation/drug effects/physiologyCell Survival/drug effects/physiologyCerebral Cortex/ cytologyGlycoside Hydrolases/metabolismHumansNeural Cell Adhesion Molecule L1Neural Cell Adhesion Molecules/genetics/ metabolism/pharmacologyNeurons/ cytology/metabolismRatsRats, Sprague-DawleyReceptor, trkB/metabolismRecombinant Fusion Proteins/genetics/metabolismRhabdomyosarcomaSialic Acids/genetics/ metabolism/pharmacologySignal Transduction/physiologyTransfectionTumor Cells, Cultured
Stable URL http://archive-ouverte.unige.ch/unige:10505
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Identifiers
PMID: 11298800
Structures
Research group Progéniteurs neuronaux
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