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Title

Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep

Authors
Petit, Brice
Neidhart, Elisabeth
Wood, P. A.
Franken, Paul
Published in Nature Genetics. 2003, vol. 34, no. 3, p. 320-325
Abstract In rodents, the electroencephalogram (EEG) during paradoxical sleep and exploratory behavior is characterized by theta oscillations. Here we show that a deficiency in short-chain acyl-coenzyme A dehydrogenase (encoded by Acads) in mice causes a marked slowing in theta frequency during paradoxical sleep only. We found Acads expression in brain regions involved in theta generation, notably the hippocampus. Microarray analysis of gene expression in mice with mutations in Acads indicates overexpression of Glo1 (encoding glyoxylase 1), a gene involved in the detoxification of metabolic by-products. Administration of acetyl-L-carnitine (ALCAR) to mutant mice significantly recovers slow theta and Glo1 overexpression. Thus, an underappreciated metabolic pathway involving fatty acid beta-oxidation also regulates theta oscillations during sleep.
Keywords Acetylcarnitine/administration & dosageAcyl-CoA DehydrogenaseAnimalsBrain/ enzymologyDisease Models, AnimalElectroencephalographyFatty Acid Desaturases/ deficiency/genetics/metabolismFatty Acids/ metabolismImmunoblottingImmunoenzyme TechniquesIn Situ HybridizationLactoylglutathione Lyase/metabolismLiver/enzymologyMaleMiceMice, Inbred AKRMice, Inbred BALB CMice, Inbred C57BLMolecular Sequence DataNootropic Agents/administration & dosageOligonucleotide Array Sequence AnalysisOxidation-ReductionSleep, REM/drug effectsTheta Rhythm
Stable URL http://archive-ouverte.unige.ch/unige:10455
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Other version: http://www.nature.com/ng/journal/v34/n3/pdf/ng1174.pdf
Identifiers
PMID: 12796782
Structures
Research group Progéniteurs neuronaux
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