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Title

Reduced amygdala activity during aversive conditioning in human narcolepsy

Authors
Ponz, Aurelie
Khatami, Ramin
Poryazova, Rositsa
Werth, Esther
Boesiger, Peter
Bassetti, C. L.
Published in Annals of Neurology. 2010, vol. 67, no. 3, p. 394-398
Abstract Narcolepsy with cataplexy is a sleep-wake disorder caused by a loss of hypothalamic hypocretins. Here we assessed the time course of amygdala activation during aversive conditioning in unmedicated patients with narcolepsy. Unlike healthy matched control subjects, narcolepsy patients had no enhancement of amygdala response to conditioned stimuli and no increase in functional coupling between the amygdala and medial prefrontal cortex. These findings suggest that human narcolepsy is accompanied by abnormal emotional learning, and that, in line with animal data, the hypocretin system and the amygdala are involved in this process.
Keywords AdultAffective Symptoms/etiology/physiopathologyAmygdala/*physiopathologyAttention/physiologyAvoidance Learning/*physiologyBiological Markers/analysis/bloodBrain MappingConditioning (Psychology)/*physiologyEmotions/physiologyFear/physiologyFemaleHumansIntracellular Signaling Peptides and Proteins/analysis/bloodLearning Disorders/etiology/*physiopathologyMagnetic Resonance ImagingMaleMiddle AgedNarcolepsy/complications/*physiopathology/*psychologyNeuropeptides/analysis/bloodNeuropsychological TestsPhotic StimulationReaction Time/physiologyYoung Adult
Stable URL http://archive-ouverte.unige.ch/unige:10391
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PMID: 20373351
Structures
Research group Neuroimagerie du Sommeil et de la Cognition (832)
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