UNIGE document Scientific Article
previous document  unige:10348  next document
add to browser collection
Title

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

Authors
Slesinger, P. A.
Published in Nature Reviews Neuroscience. 2010, vol. 11, no. 5, p. 301-315
Abstract G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in response to activation of many different G protein-coupled receptors and thus control the excitability of neurons through GIRK-mediated self-inhibition, slow synaptic potentials and volume transmission. GIRK channel function and trafficking are highly dependent on the channel subunit composition. Pharmacological investigations of GIRK channels and studies in animal models suggest that GIRK activity has an important role in physiological responses, including pain perception and memory modulation. Moreover, abnormal GIRK function has been implicated in altering neuronal excitability and cell death, which may be important in the pathophysiology of diseases such as epilepsy, Down's syndrome, Parkinson's disease and drug addiction. GIRK channels may therefore prove to be a valuable new therapeutic target.
Keywords AnimalsBrain/ metabolismBrain Diseases/metabolismG Protein-Coupled Inwardly-Rectifying Potassium Channels/ metabolismModels, NeurologicalNeurons/ metabolismPain/metabolism
Stable URL http://archive-ouverte.unige.ch/unige:10348
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.nature.com/nrn/journal/v11/n5/pdf/nrn2834.pdf
Identifiers
PMID: 20389305
Structures
Research group Mécanismes cellulaires de la dépendance et de l'addiction (520)
157 hits and 0 download since 2010-08-06
Update
Export document
Format :
Citation style :