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Title

The role of neural cell adhesion molecules in plasticity and repair

Authors
Troncoso, Edgardo
Djebbara, Z.
Published in Current Opinion in Neurobiology. 2001, vol. 36, no. 2-3, p. 175-184
Abstract Repair and functional recovery after brain injury critically depends on structural and functional plasticity of preserved neuronal networks. A striking feature of brain structures where tissue reorganization and plasticity occur is a strong expression of the polysialylated neural cell adhesion molecule (PSA-NCAM). An important role of this molecule in various aspects of neuronal and synaptic plasticity has been revealed by many studies. Recently, a new mechanism has been elucidated whereby PSA-NCAM may contribute to signalling mediated by the neurotrophic factor BDNF, thereby sensitizing neurons to this growth factor. This mechanism was shown to be important for activity-induced synaptic plasticity and for the survival and differentiation of cortical neurons. A cross-talk between these molecules may, thus, reveal a key factor for properties of structural plasticity and in particular could mediate the activity-dependent aspects of synaptic network remodeling. Animal models have been developed to assess the role of these molecules in functional recovery after lesions.
Keywords AnimalsBrain Injuries/ metabolism/physiopathologyCell Communication/physiologyHumansNerve Net/growth & development/ injuries/metabolismNeural Cell Adhesion Molecules/ metabolismNeuronal Plasticity/ physiologyRecovery of Function/ physiologySignal Transduction/physiologySynapses/metabolism
Stable URL http://archive-ouverte.unige.ch/unige:10318
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PMID: 11690614
Structures
Research group Progéniteurs neuronaux
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