Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons

Hille, B.; Beech, D. J.; Bernheim, Laurent; Mathie, A.; Shapiro, M. S.; Wollmuth, L. P.

doi:10.1016/0024-3205(95)00038-8

Scientific article

English

Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons

ContributorsHille, B.; Beech, D. J.; Bernheim, Laurent; Mathie, A.; Shapiro, M. S.; Wollmuth, L. P.

Published inLife sciences, vol. 56, no. 11-12, p. 989-992

Publication date1995

Abstract

Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.

Keywords

Alkaloids/pharmacology
Animals
Calcium Channels/ metabolism
Furans
GTP-Binding Proteins/ metabolism
Muscarinic Agonists/pharmacology
Muscarinic Antagonists/pharmacology
Naphthalenes
Neurons/drug effects/ metabolism
Oxotremorine/analogs & derivatives/pharmacology
Patch-Clamp Techniques
Pertussis Toxin
Piperidines
Pirenzepine/pharmacology
Rabbits
Rats
Receptors, Muscarinic/drug effects/ metabolism
Superior Cervical Ganglion/drug effects/ metabolism
Virulence Factors, Bordetella/pharmacology

Affiliation

Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

Citation (ISO format)

HILLE, B. et al. Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons. In: Life sciences, 1995, vol. 56, n° 11-12, p. 989–992. doi: 10.1016/0024-3205(95)00038-8

Article

Identifiers

PID : unige:10298
DOI : 10.1016/0024-3205(95)00038-8
PMID : 10188803

Commercial URLhttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T99-3YYTFYT-60-1&_cdi=5109&_user=779890&_pii=0024320595000388&_orig=search&_coverDate=02%2F10%2F1995&_sk=999439988&view=c&wchp=dGLbVzz-zSkzk&md5=d1b059892d5e3c0f5f4400255a145fd5&ie=/sdarticle.pdf

ISSN of the journal0024-3205

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Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons

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