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Title

The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation

Authors
Cvetkovic, Vesna
Machard, Daniele
Tobler, Irene
Published in Journal of Neuroscience. 2005, vol. 25, no. 16, p. 4127-4130
Abstract Sleep deprivation is accompanied by the progressive development of an irresistible need to sleep, a phenomenon whose mechanism has remained elusive. Here, we identified for the first time a reflection of that phenomenon in vitro by showing that, after a short 2 h period of total sleep deprivation, the action of noradrenaline on the wake-promoting hypocretin/orexin neurons changes from an excitation to an inhibition. We propose that such a conspicuous modification of responsiveness should contribute to the growing sleepiness that accompanies sleep deprivation.
Keywords AnimalsBlotting, Northern/methodsElectric Stimulation/methodsHypothalamus/ pathologyImmunohistochemistry/methodsIntracellular Signaling Peptides and Proteins/ metabolismMembrane Potentials/drug effects/physiology/radiation effectsNeurons/ drug effects/physiologyNeuropeptides/ metabolismNorepinephrine/ pharmacologyPatch-Clamp Techniques/methodsRNA, Messenger/biosynthesisRatsRats, Sprague-DawleyReverse Transcriptase Polymerase Chain Reaction/methodsSleep Deprivation/pathology/ physiopathologyWakefulness/ drug effects/physiology
Stable URL http://archive-ouverte.unige.ch/unige:10292
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Other version: http://www.jneurosci.org/cgi/reprint/25/16/4127.pdf
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PMID: 15843615
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