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Human myoblast differentiation: Ca(2+) channels are activated by K(+) channels

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Published in News in Physiological Sciences. 2002, vol. 17, p. 22-26
Abstract In a paradigm of cellular differentiation, human myoblast fusion, we investigated how a Ca(2+) influx, indispensable for fusion, is triggered. We show how newly expressed Kir2.1 K(+) channels, via their hyperpolarizing effect on the membrane potential, generate a window Ca(2+) current (mediated by alpha 1H T-type Ca(2+) channels), which causes intracellular Ca(2+) to rise.
Keywords Calcium Channels/ physiologyCell Differentiation/physiologyCell FusionElectrophysiologyHumansMuscle, Skeletal/ cytology/physiologyPotassium Channels, Inwardly Rectifying/ physiology
Stable URL http://archive-ouverte.unige.ch/unige:10186
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PMID: 11821532
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