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Title

Effect of opioid peptides on the paraventricular nucleus of the guinea pig hypothalamus is mediated by mu-type receptors

Authors
Wuarin, J. P.
Dreifuss, Jean-Jacques
Published in Brain Research. 1988, vol. 445, no. 2, p. 289-296
Abstract The effects of opioid peptides on paraventricular neurones were investigated by using intracellular recordings from hypothalamic slices of the guinea pig. Forty-eight out of 128 neurones were hyperpolarized by DAGO, a synthetic structural analogue of enkephalin selective for mu-receptors. This effect was concentration-dependent and reversibly suppressed by naloxone. DPLPE, a selective delta-agonist, and U-50,488, a selective kappa-agonist, had no effect. The localization and the size of the recorded perikarya were assessed following injection of the fluorescent dye Lucifer yellow. Most of the DAGO-responsive neurones were located within the paraventricular nucleus, some of them in the region of the nucleus which is rich in vasopressin-containing cells, as shown by immunocytochemistry. DAGO-sensitive cells were found among magnocellular as well as parvocellular neurones.
Keywords AnimalsEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Enkephalins/ pharmacologyGuinea PigsNaloxone/pharmacologyNeurons/drug effects/ physiologyParaventricular Hypothalamic Nucleus/drug effects/ physiologyReceptors, Opioid/drug effects/ physiologyReceptors, Opioid, mu
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PMID: 2836024
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