Effect of opioid peptides on the paraventricular nucleus of the guinea pig hypothalamus is mediated by mu-type receptors
|Published in||Brain Research. 1988, vol. 445, no. 2, p. 289-296|
|Abstract||The effects of opioid peptides on paraventricular neurones were investigated by using intracellular recordings from hypothalamic slices of the guinea pig. Forty-eight out of 128 neurones were hyperpolarized by DAGO, a synthetic structural analogue of enkephalin selective for mu-receptors. This effect was concentration-dependent and reversibly suppressed by naloxone. DPLPE, a selective delta-agonist, and U-50,488, a selective kappa-agonist, had no effect. The localization and the size of the recorded perikarya were assessed following injection of the fluorescent dye Lucifer yellow. Most of the DAGO-responsive neurones were located within the paraventricular nucleus, some of them in the region of the nucleus which is rich in vasopressin-containing cells, as shown by immunocytochemistry. DAGO-sensitive cells were found among magnocellular as well as parvocellular neurones.|
|Keywords||Animals — Enkephalin, Ala(2)-MePhe(4)-Gly(5)- — Enkephalins/ pharmacology — Guinea Pigs — Naloxone/pharmacology — Neurons/drug effects/ physiology — Paraventricular Hypothalamic Nucleus/drug effects/ physiology — Receptors, Opioid/drug effects/ physiology — Receptors, Opioid, mu|
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