UNIGE document Scientific Article
previous document  unige:10146  next document
add to browser collection
Title

Effects of ketamine on the developing central nervous system

Authors
Published in Ideggyogyaszati Szemle. 2007, vol. 60, no. 3-4, p. 109-112
Abstract Ketamine is a widely used drug in pediatric anesthesia practice, acting primarily through the blockade of the N-methyl-D-aspartate (NMDA) type of glutamate receptors. A growing body of laboratory evidence, accumulated during the past few years, suggests that this drug could have potential adverse effects on the developing central nervous system. The goal of this short review is to give a brief synopsis of experimental work indicating ketamine-induced developmental neurotoxicity as well as to discuss potential limitations concerning extrapolation of these studies to clinical practice.
Keywords Anesthetics, Dissociative/ adverse effectsAnimalsBrain/ drug effects/growth & developmentCentral Nervous System/ drug effectsHumansKetamine/ adverse effectsNeurotoxicity Syndromes/ etiologyReceptors, N-Methyl-D-Aspartate/ antagonists & inhibitors/metabolism
Stable URL http://archive-ouverte.unige.ch/unige:10146
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
Identifiers
PMID: 17451049
Structures
Research group Progéniteurs neuronaux
142 hits and 0 download since 2010-08-06
Update
Export document
Format :
Citation style :