UNIGE document Scientific Article
previous document  unige:10119  next document
add to browser collection
Title

Thyrotropin-releasing hormone causes direct excitation of dorsal vagal and solitary tract neurones in rat brainstem slices

Authors
Vozzi, C.
Dreifuss, Jean-Jacques
Published in Brain Research. 1990, vol. 530, no. 1, p. 85-90
Abstract The effect of thyrotropin-releasing hormone (TRH) on neurones in the dorsal motor nucleus of the vagus and the nucleus of the solitary tract was studied using extracellular single-unit recordings from brainstem slices of the rat. About one third of vagal neurones were excited by TRH. The remaining neurones were unaffected. The lowest effective peptide concentration was around 10 nM and a half maximal effect was achieved at about 100 nM. The action of TRH persisted in a low-calcium, high-magnesium solution which blocks synaptic transmission. The biologically inactive compound, TRH-free acid, was without effect. In the nucleus of the solitary tract, one fourth of the neurones were excited by TRH; none were inhibited by this peptide. Part of the vagal TRH-responsive neurones were also excited by oxytocin and some of the solitary tract neurones sensitive to TRH also responded to vasopressin. We conclude that a fraction of neurones located in the dorsal motor nucleus of the vagus and the nucleus of the solitary tract possess functional TRH receptors. TRH may thus act as a neurotransmitter or neuromodulator in the dorsal brainstem and may participate in the regulation of autonomic functions.
Keywords AnimalsMaleMedulla Oblongata/cytology/ physiologyNeurons/ physiologyRatsRats, Inbred StrainsThyrotropin-Releasing Hormone/ physiologyVagus Nerve/cytology/physiology
Stable URL http://archive-ouverte.unige.ch/unige:10119
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
Identifiers
PMID: 2125519
Structures
136 hits and 0 download since 2010-08-06
Update
Export document
Format :
Citation style :