A role of central oxytocin in autonomic functions: its action in the motor nucleus of the vagus nerve
|Published in||Brain Research Bulletin. 1988, vol. 20, no. 6, p. 765-770|
|Abstract||Neurones located in the dorsal motor nucleus of the vagus nerve were shown, in slices from the rat brainstem, to respond to oxytocin by a concentration-dependent increase in rate of firing. A newly available oxytocin antagonist suppressed the excitatory effect of oxytocin on single neurones; this antagonism was partially reversible. Further evidence that neurones located in the dorsal motor nucleus of the vagus nerve possess oxytocin receptors was obtained from in vitro light microscopical autoradiography using [125I]-labelled oxytocin antagonist. In conjunction with data by others which showed that oxytocin antagonist microinjected into the dorsal motor nucleus of the vagus nerve blocks gastric and cardiac effects caused by stimulation of the hypothalamic paraventricular nucleus, our results suggest a role for central oxytocin in autonomic efferent activity.|
|Keywords||Animals — Autonomic Nervous System/drug effects/ physiology — Male — Membrane Potentials/drug effects — Oxytocin/pharmacology/ physiology — Rats — Rats, Inbred Strains — Vagus Nerve/drug effects/ physiology|
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