Vasopressin excites neurones located in the dorsal cochlear nucleus of the guinea-pig brainstem
|Published in||Brain Research. 1989, vol. 483, no. 1, p. 164-169|
|Abstract||The effect of arginine vasopressin (AVP) on neurones in the dorsal cochlear nucleus (DCN) of young guinea-pigs of either sex was investigated in brainstem slices. Most impaled neurones fired in a regular manner, either spontaneously or following a depolarizing current injection. AVP, at concentrations of 10-1000 nM, excited 19/19 neurones from male and 16/19 neurones from female animals. This effect of AVP was concentration-dependent and could be mimicked by the V1 agonist [Phe2,Orn8]VT. Oxytocin was less potent than AVP and a selective V2 agonist, deamino-DAVP, was without effect. Thus, a class of DCN neurones is probably endowed with functional V1 vasopressin receptors. By making use of an antibody raised against the vasopressin-related glycopeptide, dense AVP-like immunoreactivity was found in the DCN of young animals of either sex.|
|Keywords||Action Potentials/drug effects — Animals — Arginine Vasopressin/ pharmacology — Brain Stem/drug effects/metabolism/ physiology — Cochlear Nerve/drug effects/metabolism/ physiology — Female — Guinea Pigs — Male — Oxytocin/pharmacology|
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