Stimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve
|Published in||Brain Research. 1984, vol. 300, no. 1, p. 83-89|
|Abstract||Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem. Oxytocin applied to the bath at concentrations of 10(-7) M or 10(-6) M excited 79% of these cells in a concentration-dependent, reversible manner. The remaining cells were unaffected. The stimulatory effect of oxytocin was reversibly antagonized by a synthetic structural analogue known to block the peripheral, endocrine effects of neurohypophysial peptides. A selective oxytocic agonist was as potent as oxytocin, whereas vasopressin exerted a much weaker effect. We therefore suggest that neurones located in DMX are endowed with receptors for oxytocin.|
|Keywords||Animals — Arginine Vasopressin/analogs & derivatives/pharmacology — Male — Medulla Oblongata/analysis/ drug effects — Organ Specificity — Oxytocin/analogs & derivatives/ pharmacology — Rats — Rats, Inbred Strains — Receptors, Cell Surface/analysis — Receptors, Oxytocin — Stimulation, Chemical — Vagus Nerve/analysis/ drug effects|
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