fr
Article scientifique
Anglais

Stimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve

Publié dansBrain research, vol. 300, no. 1, p. 83-89
Date de publication1984
Résumé

Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem. Oxytocin applied to the bath at concentrations of 10(-7) M or 10(-6) M excited 79% of these cells in a concentration-dependent, reversible manner. The remaining cells were unaffected. The stimulatory effect of oxytocin was reversibly antagonized by a synthetic structural analogue known to block the peripheral, endocrine effects of neurohypophysial peptides. A selective oxytocic agonist was as potent as oxytocin, whereas vasopressin exerted a much weaker effect. We therefore suggest that neurones located in DMX are endowed with receptors for oxytocin.

Mots-clés
  • Animals
  • Arginine Vasopressin/analogs & derivatives/pharmacology
  • Male
  • Medulla Oblongata/analysis/ drug effects
  • Organ Specificity
  • Oxytocin/analogs & derivatives/ pharmacology
  • Rats
  • Rats, Inbred Strains
  • Receptors, Cell Surface/analysis
  • Receptors, Oxytocin
  • Stimulation, Chemical
  • Vagus Nerve/analysis/ drug effects
Citation (format ISO)
CHARPAK, S. et al. Stimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve. In: Brain research, 1984, vol. 300, n° 1, p. 83–89.
Identifiants
ISSN du journal0006-8993
536vues
0téléchargements

Informations techniques

Création06/08/2010 10:47:04
Première validation06/08/2010 10:47:04
Heure de mise à jour14/03/2023 15:57:17
Changement de statut14/03/2023 15:57:17
Dernière indexation15/01/2024 21:04:15
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack