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Title

Stimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve

Authors
Charpak, S.
Armstrong, W. E.
Dreifuss, Jean-Jacques
Published in Brain Research. 1984, vol. 300, no. 1, p. 83-89
Abstract Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem. Oxytocin applied to the bath at concentrations of 10(-7) M or 10(-6) M excited 79% of these cells in a concentration-dependent, reversible manner. The remaining cells were unaffected. The stimulatory effect of oxytocin was reversibly antagonized by a synthetic structural analogue known to block the peripheral, endocrine effects of neurohypophysial peptides. A selective oxytocic agonist was as potent as oxytocin, whereas vasopressin exerted a much weaker effect. We therefore suggest that neurones located in DMX are endowed with receptors for oxytocin.
Keywords AnimalsArginine Vasopressin/analogs & derivatives/pharmacologyMaleMedulla Oblongata/analysis/ drug effectsOrgan SpecificityOxytocin/analogs & derivatives/ pharmacologyRatsRats, Inbred StrainsReceptors, Cell Surface/analysisReceptors, OxytocinStimulation, ChemicalVagus Nerve/analysis/ drug effects
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PMID: 6329430
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