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Title

Metabolic transient studies by NMR

Authors
Schenker, K.
Barbalat, F.
Hiltbrand, E.
Cerretelli, P.
Published in International Journal of Sports Medicine. 1992, vol. 13, no. Suppl 1, p. S155-157
Abstract The time course of phosphocreatine (PC) hydrolysis in humans was measured by 31P-NMR spectroscopy (31P-NMRS) with a time resolution of 10.8 s in the gastrocnemius muscle and a relationship between muscle O2 consumption (VO2) and [PC] was derived from a bioenergetic model. This allowed a direct estimate of the half-time of the intracellular VO2 kinetics (t1/2 VO2) of the contracting human gastrocnemius in aerobic conditions. t1/2 VO2 was found to be approximately 16 s and independent of the work load. This value corresponds to the shortest t1/2 VO2 determined at the mouth of the subject in the absence of lactate accumulation in the rest to work transient. t1/2 VO2 may now be assessed in man at low muscle temperatures. To this aim a procedure was developed allowing corrections of the 31P-NMR spectra based on the muscle temperature profiles obtained by a simultaneously acquired proton image.
Keywords Adenosine Triphosphate/biosynthesisBody Temperature/physiologyEnergy Metabolism/physiologyExercise/physiologyHumansHydrolysisMagnetic Resonance SpectroscopyMuscles/ metabolismOxygen Consumption/physiologyPhosphocreatine/metabolism
Stable URL http://archive-ouverte.unige.ch/unige:10030
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PMID: 1483759
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