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Title

Stressor-specific increase of vasopressin mRNA in paraventricular hypophysiotrophic neurons

Authors
Bartanusz, V.
Steimer, T.
Baffi, J.
Published in Neuroscience Letters. 1994, vol. 170, no. 1, p. 35-38
Abstract Cellular levels of vasopressin (VP) and corticotropin-releasing factor (CRF) RNA transcripts were determined in hypophysiotrophic neurons after open-field and immobilization stress using quantitative in situ hybridization. We found that 8 min open-field stress is sufficient to produce a significant up-regulation of CRF mRNA, without any concomitant changes in the level of VP mRNA. In contrast, 8 min immobilization stress resulted in an increased labeling density of both CRF and VP mRNAs. These results suggest that the level of CRF and VP transcripts in parvicellular hypophysiotrophic neurons is differentially regulated in a stressor-specific manner.
Keywords AnimalsAutoradiographyCorticotropin-Releasing Hormone/ biosynthesisImmobilizationIn Situ HybridizationMaleNeurons/ metabolismOligonucleotides/metabolismPituitary Gland, Posterior/cytology/ metabolismRNA, Messenger/ biosynthesisRatsRats, Inbred WKYStress, Psychological/ metabolismVasopressins/ biosynthesis
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Identifiers
PMID: 8041509
Structures
Research group Progéniteurs neuronaux
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