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Title

Solvatochromic analysis of the retention mechanism of 2 novel stationary phases used for measuring lipophilicity by Rp-Hplc

Authors
Vallat, P.
Fan, W. Z.
el Tayar, Nabil
Testa, Bernard
Published in Journal of Liquid Chromatography. 1992, vol. 15, no. 12, p. 2133-2151
Abstract The lipophilicity of a large set of solute was measured by reversed-phase high-performance liquid chromatography using two novel stationary phases, namely an octadecyl polyvinyl-alcohol copolymer (ODP) and an octyl-silane (OS) phase. Solvatochromic analysis of the results showed the ODP/buffer system to bear a close resemblance to 1-octanol/buffer system. In contrast, the OS phase is a stronger H-bond acceptor than 1-octanol and will lead to overestimating the lipophilicity of strong H-bond donor solutes
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